A colony gets attacked by "different" Predators, ones who attack everybody, enjoy pure killing (not hunting) and are able to control Aliens. Marines contact the only human who has spent time along with Predators, so that she not only helps them but tries to forge an alliance with the hunting Predators against this killers breed.
With this plot AVP Three World War delivers an exciting journey, along which we will learn more about the tribal rituals, code of honor and behaviour of traditional Predators, watch lots of action and in general have a good time with this clash of monsters.
One of those comics that goes out of the traditional safe path to offer a good story without destroying the existing lore of the alien species. Recommended if you are a fan of AvP.